PLASMA AMINO-ACID PROFILE IN THE ELDERLY WITH INCREASING UREMIA

被引：11

作者：

CARR, SJ ^{[1
]}

LAYWARD, E ^{[1
]}

BEVINGTON, A ^{[1
]}

HATTERSLEY, J ^{[1
]}

WALLS, J ^{[1
]}

机构：

[1] LEICESTER ROYAL INFIRM,DEPT CHEM PATHOL,LEICESTERSHIRE PATHOL SERV,LEICESTER,ENGLAND

来源：

NEPHRON | 1994年 / 66卷 / 02期

关键词：

AMINO ACIDS; UREMIA;

D O I：

10.1159/000187806

中图分类号：

R5 [内科学]; R69 [泌尿科学（泌尿生殖系疾病）];

学科分类号：

1002 ; 100201 ;

摘要：

Abnormalities in plasma amino acid profiles have been reported in severe uraemia and dialysis patients and may be a consequence of altered protein metabolism in the presence of metabolic acidosis. We studied plasma amino acid profiles in 7 control subjects [GFR 92.7 +/- (SEM) 14.5 ml/min/1.73 m(2)] and 7 elderly patients with renal failure (GFR 16.5 +/- 1.3 ml/min/1.73 m(2)). Uraemic patients had significantly reduced plasma levels of valine, tyrosine, phenylalanine, tryptophan and elevated histidine compared to controls. There was no correlation between arterial pH or bicarbonate and plasma amino acid levels.

引用

页码：228 / 230

页数：3

共 17 条

[1]

ALVESTRAND A, 1982, CLIN NEPHROL, V18, P297

[2]

Alvestrand A, 1983, Kidney Int Suppl, V16, pS9

[3] EFFECT OF ESSENTIAL AMINO-ACID SUPPLEMENTATION ON MUSCLE AND PLASMA-FREE AMINO-ACIDS IN CHRONIC UREMIA [J].

ALVESTRAND, A ;

BERGSTROM, J ;

FURST, P ;

GERMANIS, G ;

WIDSTAM, U .

KIDNEY INTERNATIONAL, 1978, 14 (04) :323-329

[4] PLASMA AND MUSCLE FREE AMINO-ACIDS IN MAINTENANCE HEMODIALYSIS-PATIENTS WITHOUT PROTEIN-MALNUTRITION [J].

BERGSTROM, J ;

ALVESTRAND, A ;

FURST, P .

KIDNEY INTERNATIONAL, 1990, 38 (01) :108-114

[5] INTRACELLULAR FREE AMINO-ACIDS IN MUSCLE-TISSUE OF PATIENTS WITH CHRONIC UREMIA - OF PERITONEAL-DIALYSIS AND INFUSION OF ESSENTIAL AMINO-ACIDS [J].

BERGSTROM, J ;

FURST, P ;

NOREE, LO ;

VINNARS, E .

CLINICAL SCIENCE AND MOLECULAR MEDICINE, 1978, 54 (01) :51-60

[6]

COLES GA, 1972, Q J MED, V41, P25

[7]

FURST P, 1980, AM J CLIN NUTR, V33, P1387

[8] EVALUATION OF AMINO ACID AND PROTEIN REQUIREMENTS IN CHRONIC UREMIA [J].

GULYASSY, PF ;

AVIRAM, A ;

PETERS, JH .

ARCHIVES OF INTERNAL MEDICINE, 1970, 126 (05) :855-&

[9]

HARA Y, IN PRESS KIDNEY INT

[10]

KOPPLE JD, 1978, KIDNEY INT, V14, P340, DOI 10.1038/ki.1978.134

← 1 2 →