NORMAL-MODE ANALYSIS OF PROTEIN DYNAMICS

被引：334

作者：

CASE, DA

机构：

[1] DA Case, Department of Molecular Biology, The Scripps Research Institute, La Jolla

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 1994年 / 4卷 / 02期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0959-440X(94)90321-2

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Notable recent developments in the use of normal mode methods to study protein dynamics include the use of quasiharmonic descriptions in crystallographic and NMR refinement protocols, and the development of techniques that can be applied to disordered systems (such as liquids) that do not oscillate about a single minimum. Harmonic models can also be used to investigate quantum effects and to provide a compact description of correlated motions in biomolecules. This sort of analysis has both prospects and limitations.

引用

页码：285 / 290

页数：6

共 54 条

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