THE INFLUENCE OF PARTICLE-SIZE OF LIPOSOMES ON THE DEPOSITION OF DRUG INTO SKIN

被引：150

作者：

DUPLESSIS, J ^{[1
]}

RAMACHANDRAN, C ^{[1
]}

WEINER, N ^{[1
]}

MULLER, DG ^{[1
]}

机构：

[1] UNIV MICHIGAN, COLL PHARM, ANN ARBOR, MI 48109 USA

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1994年 / 103卷 / 03期

关键词：

TOPICAL DELIVERY; LIPOSOME; PARTICLE SIZE; CYCLOSPORINE;

D O I：

10.1016/0378-5173(94)90178-3

中图分类号：

R9 [药学];

学科分类号：

1007 [药学];

摘要：

The effect of particle size of liposomes on the deposition of drugs into the strata of skin was evaluated using hairless mice, hamster and pig skin. In vitro diffusion studies were performed in an attempt to find an optimum formulation for topical drug delivery as well as to try to explain the mechanism of topical drug delivery by liposomes. The results indicate that an optimum particle size for optimal drug delivery exists. The study proved that the follicular route play an important role in determining the kinetics of drug transfer from liposomes into the skin.

引用

页码：277 / 282

页数：6

共 17 条

[1]

TOPICAL DELIVERY OF LIPOSOMALLY ENCAPSULATED GAMMA-INTERFERON [J].