CORRELATION OF INTERLEUKIN-2 RECEPTOR AND NEOPTERIN SECRETION IN RHEUMATOID-ARTHRITIS

被引：15

作者：

KULLICH, W

机构：

[1] Ludwig Boltzmann Institute for Rehabilitation of Internal Diseases, Saalfelden, A-5760

来源：

CLINICAL RHEUMATOLOGY | 1993年 / 12卷 / 03期

关键词：

INTERLEUKIN-2; RECEPTOR; NEOPTERIN; RHEUMATOID ARTHRITIS; IMMUNOREGULATION;

D O I：

10.1007/BF02231585

中图分类号：

R5 [内科学];

学科分类号：

1002 [临床医学]; 100201 [内科学];

摘要：

In rheumatoid arthritis (RA) an immuno dysregulation alters the release of neopterin from human monocytes/macrophages, probably by activation of a feed-back regulation mechanism in pterin metabolism. With the overactivation of T-lymphocytes, the secretion of interleukin-2 and its receptor (IL-2R) is influenced. Investigation on 84 RA patients has shown that this immunoactivation is accompanied by an increased secretion of neopterin and soluble IL-2R in the serum, and that both parameters are very suitable for detection of inflammatory disease activity. The significant correlation between neopterin and IL-2R (r = 0.65; p less-than-or-equal-to 0.001) in RA points out a possible connection in pathomechanisms of the immune system.

引用

页码：387 / 391

页数：5

共 23 条

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