SHORT ECHO TIME PROTON SPECTROSCOPY OF THE BRAIN IN HIV-INFECTION AIDS

被引：17

作者：

PALEY, M

WILKINSON, ID

HALLCRAGGS, MA

CHONG, WK

CHINN, RJS

HARRISON, MJG

机构：

[1] MRI Unit, The Middlesex Hospital, University College London Hospitals, London

来源：

MAGNETIC RESONANCE IMAGING | 1995年 / 13卷 / 06期

关键词：

MAGNETIC RESONANCE (MR); SPECTROSCOPY; HUMAN IMMUNODEFICIENCY VIRUS (HIV);

D O I：

10.1016/0730-725X(95)00052-I

中图分类号：

R8 [特种医学]; R445 [影像诊断学];

学科分类号：

1002 ; 100207 ; 1009 ;

摘要：

Short echo time proton spectra have been acquired from the brains of 30 male homosexual Acquired Immunodeficiency Syndrome (AIDS) patients and 12 age-matched control subjects on a 1.5 T MR system. The acquisition protocol used stimulated acquisition voxel localisation with a voxel size of 8 ml and repeat, echo, and mixing times of 5000, 20, and 30 ms, respectively. A single 25.6-ms Gaussian water suppression pulse was used with 128 spectral acquisitions and the data were eddy current corrected using a water reference. Baseline-corrected spectra were nonlinearly least squares fitted to a model function consisting of Gaussian functions representing the major metabolites reported in short echo proton spectra. Results indicate that the N-acetyl/creatine (NA/Cr) ratio is significantly reduced by 20% in AIDS patients [NA/Cr = 1.91 (0.51)] compared to control subjects [NA/Cr = 2.37 (0.25)] at short echo times.

引用

页码：871 / 875

页数：5

共 15 条

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