DIFFERENTIAL-EFFECTS OF ALPHA-ADRENOCEPTOR BLOCKADE ON ESSENTIAL, PHYSIOLOGICAL AND ISOPRENALINE-INDUCED TREMOR - EVIDENCE FOR A CENTRAL ORIGIN OF ESSENTIAL TREMOR

被引：11

作者：

ABILA, B ^{[1
]}

WILSON, JF ^{[1
]}

MARSHALL, RW ^{[1
]}

RICHENS, A ^{[1
]}

机构：

[1] UNIV WALES, COLL MED, DEPT PHARMACOL & THERAPEUT, HEATH PK, CARDIFF CF4 4XN, WALES

来源：

JOURNAL OF NEUROLOGY NEUROSURGERY AND PSYCHIATRY | 1985年 / 48卷 / 10期

关键词：

D O I：

10.1136/jnnp.48.10.1031

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Intravenous thymoxamine reduced the power of essential tremor but increased that of physiological and isoprenaline-induced tremor. These findings indicate that essential and physiological tremor have dissimilar pathophysiological mechanisms. They also suggest that central adrenergic mechanisms are involved in the pathophysiology of essential tremor and that isoprenaline-induced tremor is not a good model of essential tremor. Furthermore, alpha-adrenoceptor blockers may be a useful therapy for essential tremor.

引用

页码：1031 / 1036

页数：6

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