IMMUNOHISTOCHEMICAL EXPRESSION OF GLUTATHIONE-S-TRANSFERASE PLACENTAL TYPE (GST-PI), A DETOXIFYING ENZYME, IN NORMAL ARACHNOID VILLI AND MENINGIOMAS

被引：4

作者：

HARA, A ^{[1
]}

YAMADA, H ^{[1
]}

SAKAI, N ^{[1
]}

HIRAYAMA, H ^{[1
]}

TANAKA, T ^{[1
]}

MORI, H ^{[1
]}

机构：

[1] GIFU UNIV,SCH MED,DEPT PATHOL,GIFU 500,JAPAN

来源：

VIRCHOWS ARCHIV A-PATHOLOGICAL ANATOMY AND HISTOPATHOLOGY | 1990年 / 417卷 / 06期

关键词：

ARACHNOID VILLI; MENINGIOMA; GLUTATHIONE S-TRANSFERASE PLACENTAL TYPE; CEREBROSPINAL FLUID;

D O I：

10.1007/BF01625729

中图分类号：

R602 [外科病理学、解剖学]; R32 [人体形态学];

学科分类号：

100101 ;

摘要：

Human normal dura mater containing arachnoid villi were examined for their expression of glutathione S-transferase placental type (GST-pi), a detoxifying enzyme, using an immunohistochemical method. All of the arachnoid villi and arachnoid cells in five normal cases were found to have expression of GST-pi, although no positive reaction for the enzyme was present in other tissues of the dura mater. The results show a possible role for arachnoid tissues in protecting human brain from hazardous xenobiotics in the cerebrospinal fluid. Twenty-six meningiomas were also examined for expression of the enzyme. Tissues of meningotheliomatous meningiomas were always positive for expression of the enzyme. Transitional meningiomas also showed the expression in their meningotheliomatous components. No staining reaction of GST-pi was recogized in fibroblastic meningiomas except for two cases with a tendency to meningotheliomatous differentiation. The findings suggest a functional similarity between the arachnoid tissues and meningotheliomatous components of meningiomas.

引用

页码：493 / 496

页数：4

共 18 条

[1]

Chasseaud L F, 1979, Adv Cancer Res, V29, P175, DOI 10.1016/S0065-230X(08)60848-9

[2]

DIILIO C, 1988, CARCINOGENESIS, V9, P335

[3] RAT-LIVER GLUTATHIONE S-TRANSFERASES - A STUDY OF THE STRUCTURE OF THE BASIC YBYB-CONTAINING ENZYMES [J].