PRESENCE OF A SOLUBLE FORM OF ACETYLCHOLINESTERASE IN HUMAN OCULAR FLUIDS

被引：14

作者：

APPLEYARD, ME

MCDONALD, B

BENJAMIN, L

机构：

[1] UNIV OXFORD,OXFORD OX2 6AW,ENGLAND

[2] JOHN RADCLIFFE HOSP,NUFFIELD DEPT PATHOL & BACTERIOL,OXFORD OX3 9DU,ENGLAND

[3] UNIV OXFORD,DEPT PHARMACOL,OXFORD OX1 3QT,ENGLAND

[4] MRC,NEUROANAT PHARMACOL UNIT,OXFORD OX1 3QT,ENGLAND

[5] OXFORD EYE HOSP,OXFORD OX2 6AW,ENGLAND

来源：

BRITISH JOURNAL OF OPHTHALMOLOGY | 1991年 / 75卷 / 05期

基金：

英国惠康基金;

关键词：

D O I：

10.1136/bjo.75.5.276

中图分类号：

R77 [眼科学];

学科分类号：

100212 ;

摘要：

Samples of ocular fluid obtained from normal persons at necropsy and during eye surgery have been assayed for the presence of acetylcholinesterase. Measurable levels could be detected in all samples examined, but levels of acetylcholinesterase in vitreous humour were consistently higher than those in aqueous humour, indicating a possible retinal origin. Polyacrylamide gel electrophoresis revealed that the enzyme of ocular fluid had the same mobility as that of acetylcholinesterase from cerebrospinal fluid. It is probable that acetylcholinesterase is secreted from neuronal structures in the retina into the ocular fluid in an analogous manner to the secretion of acetylcholinesterase from brain neurones into cerebrospinal fluid.

引用

页码：276 / 279

页数：4

共 24 条

[1] SPONTANEOUS AND CARBACHOL-EVOKED INVIVO SECRETION OF ACETYLCHOLINESTERASE FROM THE HIPPOCAMPUS OF THE RAT [J].