IMPAIRMENT OF CARBAMAZEPINE TABLET DISINTEGRATION IN PATIENTS

被引：3

作者：

KOK, WJJ

VRIJHOF, WP

机构：

[1] PHARMACHEM BV,DEPT MED,POB 552,2003 RN HAARLEM,NETHERLANDS

[2] KOONINGS JAGHT INST MENTALLY RETARDED,ARNHEM,NETHERLANDS

来源：

INTERNATIONAL JOURNAL OF PHARMACEUTICS | 1992年 / 86卷 / 2-3期

关键词：

DRUG FORMULATION; TABLET DISINTEGRATION; INVIVO STUDY;

D O I：

10.1016/0378-5173(92)90204-F

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

In a selected patient group, occurrence of incompletely disintegrated parts of carbamazepine immediate release tablets in the stool was investigated. The results show that fecal excretion of tablet parts was a common phenomenon in some patients. The conversion of carbamazepine to insoluble polymorphic forms during storage or in vivo may be a possible explanation for this result.

引用

页码：259 / 262

页数：4

共 7 条

[1] CLINICAL PHARMACOKINETICS AND PHARMACOLOGICAL EFFECTS OF CARBAMAZEPINE AND CARBAMAZEPINE-10,11-EPOXIDE - AN UPDATE [J].