A NOVEL MIMIC OF THE SIALYL-LEWIS X DETERMINANT

被引:29
作者
ALLANSON, NM
DAVIDSON, AH
MARTIN, FM
机构
[1] Medicinal Chemistry Department British Bio-technology Brook House, Oxford, OX4 5LY, Watlington Road, Cowley
关键词
D O I
10.1016/S0040-4039(00)79271-9
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
The syntheses of two novel disaccharides are described which block the interaction of the lectin domain of E-selectin with its glycosylated ligands on neutrophils.
引用
收藏
页码:3945 / 3948
页数:4
相关论文
共 19 条
[1]   SYNTHESIS AND STRUCTURAL-ANALYSIS USING 2-D NMR OF SIALYL LEWIS-X (SLE(X)) AND LEWIS-X (LE(X)) OLIGOSACCHARIDES - LIGANDS RELATED TO E-SELECTIN [ELAM-1] BINDING [J].
BALL, GE ;
ONEILL, RA ;
SCHULTZ, JE ;
LOWE, JB ;
WESTON, BW ;
NAGY, JO ;
BROWN, EG ;
HOBBS, CJ ;
BEDNARSKI, MD .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (13) :5449-5451
[2]  
BERG EL, 1991, J BIOL CHEM, V266, P14869
[3]   AN IMPROVED PROCEDURE FOR THE INTRODUCTION OF THE DELTA-LACTONE PORTION OF HMG-COA REDUCTASE INHIBITORS [J].
BLACKWELL, CM ;
DAVIDSON, AH ;
LAUNCHBURY, SB ;
LEWIS, CN ;
MORRICE, EM ;
REEVE, MM ;
ROFFEY, JAR ;
TIPPING, AS ;
TODD, RS .
JOURNAL OF ORGANIC CHEMISTRY, 1992, 57 (06) :1935-1937
[4]  
GRIECO PA, 1973, J AM CHEM SOC, V95, P3072
[5]  
HOSOMI A, 1976, TETRAHEDRON LETT, P1295
[6]   PHOSPHORUS-CONTAINING INHIBITORS OF HMG-COA REDUCTASE .1. 4-[(2-ARYLETHYL)HYDROXYPHOSPHINYL]-3-HYDROXYBUTANOIC ACIDS - A NEW CLASS OF CELL-SELECTIVE INHIBITORS OF CHOLESTEROL-BIOSYNTHESIS [J].
KARANEWSKY, DS ;
BADIA, MC ;
CIOSEK, CP ;
ROBL, JA ;
SOFIA, MJ ;
SIMPKINS, LM ;
DELANGE, B ;
HARRITY, TW ;
BILLER, SA ;
GORDON, EM .
JOURNAL OF MEDICINAL CHEMISTRY, 1990, 33 (11) :2952-2956
[7]   CONFORMATIONAL STUDIES OF SIALYL LEWIS-X IN AQUEOUS-SOLUTION [J].
LIN, YC ;
HUMMEL, CW ;
HUANG, DH ;
ICHIKAWA, Y ;
NICOLAOU, KC ;
WONG, CH .
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 1992, 114 (13) :5452-5454
[8]   SYNTHESIS OF 4-DEOXY AND 4-DEOXY-4-HALOGENO DERIVATIVES OF L-FUCOSE AS POTENTIAL ENZYME-INHIBITORS [J].
LINDHORST, TK ;
THIEM, J .
CARBOHYDRATE RESEARCH, 1991, 209 :119-129
[9]   ELAM-1-DEPENDENT CELL-ADHESION TO VASCULAR ENDOTHELIUM DETERMINED BY A TRANSFECTED HUMAN FUCOSYL-TRANSFERASE CDNA [J].
LOWE, JB ;
STOOLMAN, LM ;
NAIR, RP ;
LARSEN, RD ;
BERHEND, TL ;
MARKS, RM .
CELL, 1990, 63 (03) :475-484
[10]   LEUKOCYTE ADHESION TO ENDOTHELIUM IN INFLAMMATION [J].
OSBORN, L .
CELL, 1990, 62 (01) :3-6