ACHIRAL INTERNUCLEOSIDE LINKAGES 2 - O-CH2-CH2 LINKAGE

被引：5

作者：

CAULFIELD, TJ ^{[1
]}

PRASAD, CVC ^{[1
]}

DELECKI, DJ ^{[1
]}

PROUTY, CP ^{[1
]}

SAHA, AK ^{[1
]}

UPSON, DA ^{[1
]}

KRUSE, LI ^{[1
]}

机构：

[1] STERLING WINTHROP PHARMACEUT RES DIV,DEPT MED CHEM,COLLEGEVILLE,PA 19426

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 12期

关键词：

D O I：

10.1016/S0960-894X(01)80520-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The synthesis of an O-CH2-CH2 internucleoside linkage has been achieved. The crucial carbon to oxygen bond was formed by trapping a pi-allyl palladium complex with 3' alcohol 6. An antisense oligonucleoside containing this dimer modification hybridized to the sense sequence.

引用

页码：1497 / 1500

页数：4

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