EFFECTS OF RETINOIDS ON REGULATORY CELLULAR INTERACTIONS IN PRIMARY MIXED LYMPHOCYTE-REACTION (MLR)

被引：6

作者：

DOZMOROV, IM

LEE, SY

PARK, KC

机构：

[1] SHEMYAKIN & OVCHINNIKOV INST BIOORGAN CHEM,MOSCOW,RUSSIA

[2] CATHOLIC UNIV MED COLL,DEPT CHEM,SEOUL,SOUTH KOREA

[3] UNIV ULSAN,COLL MED,DEPT SURG,SEOUL,SOUTH KOREA

来源：

IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY | 1995年 / 17卷 / 04期

关键词：

D O I：

10.3109/08923979509037188

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The effects of two retinoids, all-trans-retinoic acid and 13-cis-retinoic acid on murine splenic lymphocyte proliferative response in mixed culture were evaluated. In contrast with previously reported absence of retinoic acid (RA) effect on mixed lymphocyte reaction (MLR) the conditions for a strong potentiation of proliferative response of murine lymphocyes with RA were obtained. Stimulatory cells were determined to be the main targets for RA. The data suggest that the RA potentiating effect is the result of an increase in stimulator cell immunogenicity after their pre-treatment with RA before use in MLR. Optimal potentiation by retinoids of proliferative response was found at non-optimal conditions of mixed culture.

引用

页码：665 / 685

页数：21

共 31 条

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