THE INCREASED PLASMA LP(A) - B-LIPOPROTEIN PARTICLE CONCENTRATION IN ANGINA-PECTORIS IS NOT ASSOCIATED WITH HYPOFIBRINOLYSIS

被引：33

作者：

ALESSI, MC

PARRA, HJ

JOLY, P

VUDAC, N

BARD, JM

FRUCHART, JC

JUHANVAGUE, I

机构：

[1] CHU TIMONE, F-13385 MARSEILLE, FRANCE

[2] FAC PHARM LILLE, F-59045 LILLE, FRANCE

[3] INST PASTEUR, SERV RECH LIPOPROT & ATHEROSCLEROSE, F-59019 LILLE, FRANCE

[4] INST PASTEUR, INSERM, U325, F-59019 LILLE, FRANCE

来源：

CLINICA CHIMICA ACTA | 1990年 / 188卷 / 02期

关键词：

Angina pectoris; B lipoprotein particle; Impaired fibrinolysis; Lp(a); Myocardial infarction; PAI-1; Plasminogen;

D O I：

10.1016/0009-8981(90)90156-M

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

The structural homology between plasminogen and apolipoprotein (a), the specific glycoprotein of Lp(a) lipoprotein, raises the possibility of a relationship between this lipoprotein and the plasma fibrinolytic system. The present study examines this proposal by studying 66 patients with angina pectoris. As compared to normal controls, the patients had raised concentrations of Lp(a): B lipoprotein particles. No correlation was found between circulating Lp(a): B and the fibrinolytic system. The pathogenic role of Lp(a): B lipoprotein seems therefore not mediated by its effect on the plasma fibrinolytic system. © 1990.

引用

页码：119 / 127

页数：9

共 39 条

[1]

AILLAUD MF, 1985, THROMB HAEMOSTASIS, V54, P466

[2] THE ASSOCIATION BETWEEN SERUM LP(A) CONCENTRATIONS AND ANGIOGRAPHICALLY ASSESSED CORONARY ATHEROSCLEROSIS - DEPENDENCE ON SERUM LDL LEVELS [J].