GROWTH-FACTOR INTERACTIONS IN CULTURES OF DISSOCIATED ADULT ACOUSTIC GANGLIA - NEURONOTROPHIC EFFECTS

被引：62

作者：

LEFEBVRE, PP

VANDEWATER, TR

WEBER, T

ROGISTER, B

MOONEN, G

机构：

[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT OTOLARYNGOL,DEV OTOBIOL LAB,1410 PELHAM PKWY S,BRONX,NY 10461

[2] YESHIVA UNIV ALBERT EINSTEIN COLL MED,DEPT NEUROSCI,BRONX,NY 10461

[3] STATE UNIV LIEGE,DEPT OTOLARYNGOL & AUDIOPHONOL,B-4000 LIEGE,BELGIUM

[4] STATE UNIV LIEGE,DEPT HUMAN PHYSIOL & PATHOPHYSIOL,B-4000 LIEGE,BELGIUM

来源：

BRAIN RESEARCH | 1991年 / 567卷 / 02期

关键词：

BASIC FIBROBLAST GROWTH FACTOR; TRANSFORMING GROWTH FACTOR BETA; NERVE GROWTH FACTOR; AUDITORY NEURON;

D O I：

10.1016/0006-8993(91)90809-A

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Auditory neurons cultured from adult rat acoustic ganglia require for survival either a substrate bound factor(s) present in astrocyte conditioned medium or substrate bound basic fibroblast growth factor (bFGF). Nerve growth factor (NGF) is not a survival factor for these neurons in vitro, but when used in combination with substrate bound bFGF, NGF does vigorously stimulate a neuritogenesis response by these neurons. Transforming growth factor-beta (TGF-beta(1)) enhances the survival effect that bFGF has on these adult auditory neurons but does not by itself promote their survival in dissociated acoustic ganglion cultures. We propose that there may be complex interactions and synergy exerted by these growth factors (i.e. bFGF, NGF, TGF-beta(1)) during injury to the inner ear.

引用

页码：306 / 312

页数：7

共 37 条

[1] BASIC FIBROBLAST GROWTH-FACTOR RELEASED FROM SYNTHETIC GUIDANCE CHANNELS FACILITATES PERIPHERAL-NERVE REGENERATION ACROSS LONG NERVE GAPS [J].