EFFECTS OF CARBAMAZEPINE ON ACUTE RESPONSES TO SMOKED COCAINE-BASE IN HUMAN COCAINE USERS

被引：36

作者：

HATSUKAMI, D ^{[1
]}

KEENAN, R ^{[1
]}

HALIKAS, J ^{[1
]}

PENTEL, PR ^{[1
]}

BRAUER, LH ^{[1
]}

机构：

[1] HENNEPIN CTY MED CTR,DEPT MED,MINNEAPOLIS,MN 55415

来源：

PSYCHOPHARMACOLOGY | 1991年 / 104卷 / 01期

关键词：

SMOKED COCAINE; CARBAMAZEPINE; HUMANS;

D O I：

10.1007/BF02244565

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

A double-blind, placebo-controlled cross-over study was conducted to determine the effects of carbamazepine on the acute physiological and subjective responses to a single dose of smoked cocaine-base. Male cocaine users (N = 6) were given 400 mg carbamazepine or placebo, each for a period of 5 days. At the end of the 5-day period, a 40 mg dose of smoked cocaine was administered. The results showed a significantly higher heart rate, diastolic blood pressure elevation, and blood pressure-heart rate product under the carbamazepine compared to the placebo condition. There were no effects of carbamazepine on the subjective responses from cocaine. The increase in cardiovascular functions indicates a need to be cautious in the use of carbamazepine in the treatment of cocaine abusers.

引用

页码：120 / 124

页数：5

共 23 条

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[2]

BEERMANN B, 1975, BRIT HEART J, V37, P668

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