DECREASE OF LIVER ENERGY-CHARGE, ATP AND GLUTATHIONE AT CONCOMITANT INTRAARTERIAL ADMINISTRATION OF ADRIAMYCIN AND DEGRADABLE STARCH MICROSPHERES IN RAT

被引：5

作者：

ELHAG, IA

ROOS, G

STENRAM, U

机构：

[1] Department of Pathology, Lund University, University Hospital

来源：

SELECTIVE CANCER THERAPEUTICS | 1990年 / 6卷 / 03期

关键词：

D O I：

10.1089/sct.1990.6.135

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Adriamycin (Adr) and degradable starch microspheres (DSM) were infused either combined or each separately into the hepatic artery in rats. Liver ATP, GTP, UDP-glucuronic acid, UDP-N-acetyl-hexosamine and energy charge and glutathione were decreased 20 min later with combined treatment but not by Adr or DSM when infused alone. The nucleotide levels were normalized 60 min after the combined treatment. After one week, the Adr rats showed a less weight gain than controls. The Adr + DSM rats lost weight. Only minor changes were found in the livers at microscopical examination at this time. © 1990, Mary Ann Liebert, Inc. All rights reserved.

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页码：135 / 144

页数：10

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