A RANDOMIZED, DOUBLE-BLIND COMPARISON OF GRANISETRON WITH HIGH-DOSE METOCLOPRAMIDE, DEXAMETHASONE AND DIPHENHYDRAMINE FOR CISPLATIN-INDUCED EMESIS - AN NCI CANADA CLINICAL-TRIALS GROUP PHASE-III TRIAL

被引：33

作者：

WARR, D

WILAN, A

VENNER, P

PATER, J

KAIZER, L

LABERGE, F

LATREILLE, J

STEWART, D

OCONNELL, G

OSOBA, D

WILSON, K

DAVIS, A

JOHNSTON, D

机构：

[1] MCMASTER UNIV, DEPT CLIN EPIDEMIOL & BIOSTAT, HAMILTON L8S 4L8, ONTARIO, CANADA

[2] CROSS CANC INST, DEPT MED, EDMONTON T6G 1Z2, ALBERTA, CANADA

[3] NATL CANC INST CANADA, CLIN TRIALS GRP, KINGSTON, ONTARIO, CANADA

[4] CREDIT VALLEY HOSP, DEPT MED, MISSISSAUGA, ONTARIO, CANADA

[5] HOP LAVAL, DEPT MED, QUEBEC CITY, QUEBEC, CANADA

[6] HOP HOTEL DIEU, DEPT MED, MONTREAL H2W 1T8, QUEBEC, CANADA

[7] OTTAWA GEN HOSP, OTTAWA REG CANC CTR, OTTAWA K1H 8L6, ONTARIO, CANADA

[8] HENDERSON GEN HOSP, DIV GYNECOL ONCOL, HAMILTON L8V 1C3, ONTARIO, CANADA

[9] BRITISH COLUMBIA CANC AGCY, DIV MED ONCOL, VANCOUVER, BC, CANADA

[10] BRITISH COLUMBIA CANC AGCY, DEPT MED, VICTORIA, BC, CANADA

[11] SMITHKLINE BEECHAM PHARMACEUT CO, MISSISSAUGA, ONTARIO, CANADA

来源：

EUROPEAN JOURNAL OF CANCER | 1993年 / 29A卷 / 01期

关键词：

D O I：

10.1016/0959-8049(93)90572-W

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

151 patients (149 evaluable) receiving their first course of chemotherapy containing cisplatin in a dose of at least 50 mg/m2 were randomised to receive either a single dose of intravenous granisetron 80 mug/kg or intravenous metoclopramide 2 mg/kg every 2 h for five doses plus a single dose of dexamethasone 10 mg and diphenhydramine. After 24 h, there was no significant difference between groups with respect to nausesa or vomiting: in the granisetron group 46% of patients had no emesis, versus 44% of the standard group. Granisetron is an antiemetic agent with efficacy similar to that of high-dose metoclopramide plus dexamethasone.

引用

页码：33 / 36

页数：4

共 16 条

[1] DEXAMETHASONE AND HIGH-DOSE METOCLOPRAMIDE - EFFICACY IN CONTROLLING CISPLATIN INDUCED NAUSEA AND VOMITING [J].