AVIDITY AND TITER OF IMMUNOGLOBULIN-G SUBCLASSES TO PORPHYROMONAS-GINGIVALIS IN ADULT PERIODONTITIS PATIENTS

被引：39

作者：

LOPATIN, DE

BLACKBURN, E

机构：

[1] Department of Biological and Materials Sciences, School of Dentistry, University of Michigan, Ann Arbor

来源：

ORAL MICROBIOLOGY AND IMMUNOLOGY | 1992年 / 7卷 / 06期

关键词：

PORPHYROMONAS-GINGIVALIS; ANTIBODY AVIDITY; LIPOPOLYSACCHARIDE; PERIODONTAL DISEASE;

D O I：

10.1111/j.1399-302X.1992.tb00632.x

中图分类号：

R78 [口腔科学];

学科分类号：

1003 ;

摘要：

The relative avidity and titer of antibodies representing the 4 immunoglobulin G (IgG) subclasses (IgG1-4) reactive with Porphyromonas gingivalis, P. gingivalis-lipopolysaccharide (-LPS), streptokinase (SK) and tetanus toxoid (TT) in the sera of patients having adult periodontitis and of healthy controls were measured. Patient antibody titers to P gingivalis and P gingivalis-LPS were found to be significantly elevated for IgG, IgG1 (no P gingivalis-LPS antibodies) and IgG2. The predominant antibody response to P gingivalis and P gingivalis-LPS occurred in the IgG2 subclass. When the relative avidity of the antibodies to P gingivalis and P gingivalis-LPS were examined, no significant differences between control and patient sera could be identified. However, anti-P gingivalis and P gingivalis-LPS antibodies were found to possess significantly lower relative avidity than either SK or TT antibodies. The IgG1 subclass antibodies to P gingivalis, SK and TT all appeared to be of high relative avidity. In contrast, anti-P gingivalis and P gingivalis-LPS of the IgG2 subclass were of significantly lower relative avidity. Since the predominant humoral response to P gingivalis occurs in the IgG2 subclass, the low relative avidity of these antibodies predominates in measurements of whole serum activity.

引用

页码：332 / 337

页数：6

共 42 条

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