PRODUCTION OF PROSTANOIDS BY LEWIS RAT SCHWANN-CELLS IN-VITRO

被引：33

作者：

CONSTABLE, AL ^{[1
]}

ARMATI, PJ ^{[1
]}

TOYKA, KV ^{[1
]}

HARTUNG, HP ^{[1
]}

机构：

[1] UNIV WURZBURG,DEPT NEUROL,W-8700 WURZBURG,GERMANY

来源：

BRAIN RESEARCH | 1994年 / 635卷 / 1-2期

关键词：

SCHWANN CELL; PROSTANOID; PROSTAGLANDIN; THROMBOXANE; INFLAMMATION;

D O I：

10.1016/0006-8993(94)91425-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 [神经生物学];

摘要：

Schwann cells may play a role in the pathogenesis of autoimmune inflammatory diseases of peripheral nerve. They are the targets of autoimmune attack but may also act as antigen presenting cells. Here we investigate the possibility that Schwann cells may be able to modulate T-cell mediated immunity via prostanoid production. The results show that Lewis rat Schwann cells in vitro generate significant amounts of the pro-inflammatory and immunoregulatory mediators, prostaglandin E(2) and thromboxane A(2) and so may influence autoimmune inflammatory reactions within the peripheral nervous system.

引用

页码：75 / 80

页数：6

共 38 条

[1]

Alberts B, 2017, MOL BIOL CELL

[2]

INTERACTIONS BETWEEN CD4+ T-CELLS AND RAT SCHWANN-CELLS INVITRO .1. ANTIGEN PRESENTATION BY LEWIS RAT SCHWANN-CELLS TO P2-SPECIFIC CD4+ T-CELL LINES [J].