CYTOKINE GENE AND CD25 ANTIGEN EXPRESSION BY PERIPHERAL-BLOOD T-CELLS FROM PATIENTS WITH PRIMARY SJOGRENS-SYNDROME

被引：12

作者：

VILLARREAL, GM ^{[1
]}

ALCOCERVARELA, J ^{[1
]}

LLORENTE, L ^{[1
]}

机构：

[1] INST NACL NUTR SALVADOR ZUBIRAN,DEPT IMMUNOL & RHEUMATOL,MEXICO CITY 14000,DF,MEXICO

来源：

AUTOIMMUNITY | 1995年 / 20卷 / 04期

关键词：

PRIMARY SJOGRENS SYNDROME; INTERLEUKIN; 2; RECEPTOR; T CELL ACTIVATION; INTERFERON-GAMMA; INTERLEUKIN-10; INTERLEUKIN-13;

D O I：

10.3109/08916939508995699

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We studied mononuclear cell subsets in 17 patients with primary Sjogren's syndrome (PSS) and in 11 normal controls by now cytometry. We found a decreased percentage of CD4 + cells (p = 0.027) and a higher percentage of CD8 + cells in patients as compared to controls. In both, CD4 + cells and CD8 + cells, CD25 antigen was overexpressed (p = 0.005 and p = 0.025, respectively as compared to controls). We then measured spontaneous mRNA cytokine expression by T cells from 7 PSS patients and 5 normal controls by coupled reverse transcription-polymerase chain reaction. We found spontaneous mRNA expression for IFN-gamma, IL-10, IL-13 as well as for CD25. Our results suggest an overall T cell activation in PSS patients and provides evidence of a T cell cytokine regulatory imbalance which may play a role in the pathogenesis of this disease.

引用

页码：223 / 229

页数：7

共 31 条

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