INCREASED NITRIC-OXIDE PRODUCTION IN PATIENTS WITH HYPOTENSION DURING HEMODIALYSIS

被引：110

作者：

YOKOKAWA, K ^{[1
]}

MANKUS, R ^{[1
]}

SAKLAYEN, MG ^{[1
]}

KOHNO, M ^{[1
]}

YASUNARI, K ^{[1
]}

MINAMI, M ^{[1
]}

KANO, H ^{[1
]}

HORIO, T ^{[1
]}

TAKEDA, T ^{[1
]}

MANDEL, AK ^{[1
]}

机构：

[1] WRIGHT STATE UNIV, DAYTON, OH 45435 USA

来源：

ANNALS OF INTERNAL MEDICINE | 1995年 / 123卷 / 01期

关键词：

D O I：

10.7326/0003-4819-123-1-199507010-00005

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: To determine the involvement of nitric oxide production in hemodialysis-induced hypotension. Design: Examination of nitric oxide synthesis, cyclic guanosine 3'5'-monophosphate (cGMP) levels, and endothelin-1 levels in plasma before and after hemodialysis. Setting: Veterans Affairs medical center. Patients: 13 patients with end-stage renal failure who were receiving hemodialysis: Six patients had hypotensive episodes during dialysis and 7 did not. Intervention: Patients received heparin at a bolus dose of 2000 U at the initiation of dialysis followed by 1000 U/h during 4-hour hemodialysis sessions. Results: Nitric oxide production markedly increased during hemodialysis-induced hypotensive episodes; this increase was not seen in patients who did not have a hypotensive episode. In both groups, the plasma cGMP and endothelin-1 levels decreased after hemodialysis. According to multiple regression analysis, standard coefficients of nitric oxide production, plasma cGMP levels, and endothelin-1 levels with mean blood pressure after hemodialysis were -0.743, -0.07, and 0.31, respectively. Conclusion: Nitric oxide production increased in patients who had a hypotensive episode during hemodialysis but did not increase in those who did not have a hypotensive episode.

引用

页码：35 / 37

页数：3

共 12 条

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