INVOLVEMENT OF SINGLET OXYGEN IN PHOTOACTIVATION OF AFLATOXINS B1 AND B2 TO DNA-BINDING FORMS INVITRO

被引：13

作者：

STARK, AA ^{[1
]}

GAL, Y ^{[1
]}

SHAULSKY, G ^{[1
]}

机构：

[1] TEL AVIV UNIV,DEPT BIOCHEM,IL-69978 TEL AVIV,ISRAEL

来源：

CARCINOGENESIS | 1990年 / 11卷 / 04期

关键词：

D O I：

10.1093/carcin/11.4.529

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

UVA-activated aflatoxin B1 (AFB1) and AFB2 bound covalently to DNA. The rate of binding increased in D2O versus H2O and decreased by diazabicyclo-odane, azide, aniline, 2-naphthylamine and by efficient strip ing of oxygen. P Similarly to DNA-binding, singlet oxygen (1O2 formation increased in D2O and was inhibited by singlet scavengers, as judged by the formation of malonaldehyde from linolenic acid. The above argue for the involvement of 1O2 in aflatoxin photoactivation to DNA-binding species. A model for the mechanism is proposed. © 1990 Oxford University Press.

引用

页码：529 / 534

页数：6

共 39 条

[1] DYE BINDING AND PHOTODYNAMIC-ACTION [J].