THE INHIBITION BY PERTUSSIS AND TETANUS TOXINS OF EVOKED CATECHOLAMINE RELEASE FROM INTACT AND PERMEABILIZED BOVINE ADRENAL CHROMAFFIN CELLS

被引：7

作者：

BANSAL, MK ^{[1
]}

PHILLIPS, JH ^{[1
]}

VANHEYNINGEN, S ^{[1
]}

机构：

[1] UNIV EDINBURGH, DEPT BIOCHEM, HUGH ROBSON BLDG, GEORGE SQ, EDINBURGH EH8 9XD, SCOTLAND

来源：

FEBS LETTERS | 1990年 / 276卷 / 1-2期

基金：

英国惠康基金;

关键词：

TETANUS TOXIN; PERTUSSIS TOXIN; ADRENAL CELL; CATECHOLAMINE; EXOCYTOSIS;

D O I：

10.1016/0014-5793(90)80533-O

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Pertussis toxin stimulates both basal and nicotine-evoked catecholamine secretion from intact bovine adrenal chromaffin cells, as well as Ca2+ -evoked release from permeabilized cells. Tetanus toxin inhibits all these effects; it reduces the secretion of intact cells treated with pertussis toxin to the basal level, and decreases by about 50% Ca2+ -evoked release from permeabilized cells whether or not previously stimulated by pertussis toxin.

引用

页码：165 / 168

页数：4

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