HEMOGLOBIN-ACETALDEHYDE ADDUCTS IN HUMAN VOLUNTEERS FOLLOWING ACUTE ETHANOL INGESTION

被引：50

作者：

NIEMELA, O

ISRAEL, Y

MIZOI, Y

FUKUNAGA, T

ERIKSSON, CJP

机构：

[1] UNIV TORONTO,DEPT PHARMACOL,TORONTO M5S 1A8,ONTARIO,CANADA

[2] ALKO LTD,RES LABS,SF-00101 HELSINKI,FINLAND

[3] UNIV TORONTO,ADDICT RES FDN,TORONTO M5S 1A8,ONTARIO,CANADA

[4] KOBE UNIV,SCH MED,DEPT LEGAL MED,KOBE 650,JAPAN

来源：

ALCOHOLISM-CLINICAL AND EXPERIMENTAL RESEARCH | 1990年 / 14卷 / 06期

关键词：

Ethanol Metabolism; Heavy Drinking; Immunoassay;

D O I：

10.1111/j.1530-0277.1990.tb01824.x

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Rabbit antibodies against albumin‐acetaldehyde adduct were used in an enzyme‐linked immunosorbent assay to detect acetaldehyde‐hemoglobin condensates from the blood of 12 volunteers following ingestion of 1.3 to 2.9 g of ethanol per kg body weight during 8 hr. Blood samples were drawn before drinking and between 2 to 46 hr after starting the drinking session. While there were no significant increases in blood acetaldehyde levels in these samples, acetaldehyde‐hemoglobin adducts were significantly increased in the samples drawn after ethanol had been eliminated from the body. Administration of ethanol (0.1 g/kg) to an Oriental flusher resulted in an increase both in blood acetaldehyde and the hemoglobin‐acetaldehyde adduct levels. These results suggest that acetaldehyde‐hemoglobin condensates are formed in vivo following acute ethanol ingestion. Such condensates may be of value to mark alcohol consumption. Copyright © 1990, Wiley Blackwell. All rights reserved

引用

页码：838 / 841

页数：4

共 19 条

[1] HUMAN-BLOOD ACETALDEHYDE CONCENTRATION DURING ETHANOL OXIDATION (UPDATE 1982) [J].