INHIBITION OF UREASE ACTIVITY BY DIPEPTIDYL HYDROXAMIC ACIDS

被引：29

作者：

ODAKE, S

NAKAHASHI, K

MORIKAWA, T

TAKEBE, S

KOBASHI, K

机构：

[1] FUJI CHEM IND CO LTD, RES INST, 530 CHOKEIJI, TOYAMA 933, JAPAN

[2] TOYAMA MED & PHARMACEUT UNIV, FAC PHARMACEUT SCI, TOYAMA, TOYAMA 93001, JAPAN

来源：

CHEMICAL & PHARMACEUTICAL BULLETIN | 1992年 / 40卷 / 10期

关键词：

UREASE; HYDROXAMIC ACID; INHIBITOR; DIPEPTIDE;

D O I：

10.1248/cpb.40.2764

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of dipeptidyl hydroxamic acids (H-X-Cly-NHOH: X = amino acid residues) was synthesized, and the inhibitory activity against Jack bean and Proteus mirabilis ureases [EC 3.5.1.5] was examined. A number of H-X-Gly-NHOH inhibited Jack bean urease with an I50 of the order of 10(-6) m and inhibited Proteus mirabilis urease with an I50 of the order of 10(-5) m. The inhibition against Jack bean urease was more potent than that with the corresponding aminoacyl hydroxamic acids (H-X-NHOH).

引用

页码：2764 / 2768

页数：5

共 25 条

[1] SOME MICROMETHODS FOR ENZYME STUDIES [J].