BENZOLACTAM GROWTH-HORMONE SECRETAGOGUES - CARBOXAMIDES AS REPLACEMENTS FOR THE 2'-TETRAZOLE MOIETY OF L-692,429

被引：19

作者：

DEVITA, RJ ^{[1
]}

SCHOEN, WR ^{[1
]}

FISHER, MH ^{[1
]}

FRONTIER, AJ ^{[1
]}

PISANO, JM ^{[1
]}

WYVRATT, MJ ^{[1
]}

CHENG, K ^{[1
]}

CHAN, WWS ^{[1
]}

BUTLER, BS ^{[1
]}

HICKEY, GJ ^{[1
]}

JACKS, TM ^{[1
]}

SMITH, RG ^{[1
]}

机构：

[1] MERCK & CO INC,DEPT BASIC ANIM SCI RES,RAHWAY,NJ 07065

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1994年 / 4卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(00)80080-3

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A variety of 2'-carboxamides was investigated as replacements for the 2'-tetrazole moiety of L692,429. Investigation of the structure-activity relationships of the carboxamide series determined that primary and secondary carboxamides are potent growth hormone secretagogues in vitro, L-700,653(11) was identified as an orally active GH secretagogue in dogs.

引用

页码：2249 / 2254

页数：6

共 9 条

[1]

CHANG CH, JUL AM SOC AN SCI M

[2]

CHENG K, 1989, ENDOCRINOLOGY, V124, P2791

[3] BENZOLACTAM GROWTH-HORMONE SECRETAGOGUES - REPLACEMENTS FOR THE 2'-TETRAZOLE MOIETY OF L-692,429 [J].

DEVITA, RJ ;

SCHOEN, WR ;

OK, D ;

BARASH, L ;

BROWN, JE ;

FISHER, MH ;

HODGES, P ;

WYVRATT, MJ ;

CHENG, K ;

CHAN, WWS ;

BUTLER, BS ;

SMITH, RG .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (15) :1807-1812

[4] TOTAL SYNTHESIS OF BIOLOGICALLY IMPORTANT AMINO-SUGARS VIA THE NITROALDOL REACTION [J].

HANESSIAN, S ;

KLOSS, J .

TETRAHEDRON LETTERS, 1985, 26 (10) :1261-1264

[5] PREPARATION AND STORAGE OF (R)-2,3-O-ISOPROPYLIDENEGLYCERALDEHYDE (D-GLYCERALDEHYDE ACETONIDE) [J].

HERTEL, LW ;

GROSSMAN, CS ;

KROIN, JS .

SYNTHETIC COMMUNICATIONS, 1991, 21 (02) :151-154

[6]

OK D, UNPUB

[7] A NOVEL 3-SUBSTITUTED BENZAZEPINONE GROWTH-HORMONE SECRETAGOGUE (L-692,429) [J].

SCHOEN, WR ;

PISANO, JM ;

PRENDERGAST, TK ;

WYVRATT, MJ ;

FISHER, MH ;

CHENG, K ;

CHAN, WWS ;

BUTLER, B ;

SMITH, RG ;

BALL, RG .

JOURNAL OF MEDICINAL CHEMISTRY, 1994, 37 (07) :897-906

[8] STRUCTURE-ACTIVITY-RELATIONSHIPS IN THE AMINO-ACID SIDE-CHAIN OF L-692,429 [J].

SCHOEN, WR ;

OK, D ;

DEVITA, RJ ;

PISANO, JM ;

HODGES, P ;

CHENG, K ;

CHAN, WWS ;

BUTLER, BS ;

SMITH, RG ;

WYVRATT, MJ ;

FISHER, MH .

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 1994, 4 (09) :1117-1122

[9]

SCHOEN WR, 1993, ANNU REP MED CHEM, V28, pCH19

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