EXPERIMENTAL TRANSMISSION OF HANTAVIRUS INFECTION IN LABORATORY RATS

被引：22

作者：

DOHMAE, K ^{[1
]}

OKABE, M ^{[1
]}

NISHIMUNE, Y ^{[1
]}

机构：

[1] OSAKA UNIV, MICROBIAL DIS RES INST, SUITA, OSAKA 565, JAPAN

来源：

JOURNAL OF INFECTIOUS DISEASES | 1994年 / 170卷 / 06期

关键词：

D O I：

10.1093/infdis/170.6.1589

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

This study found a competent transmission of hantavirus between cagemates using congenitally T cell-deficient Rowett nude rats (rnu/rnu). Intraperitoneally infected immunologically normal rats (rnu/+) did not transmit the hantavirus to their normal cagemates (rnu/+) but did to Rowett nude rats (rnu/rnu). Thus, nude rats were shown to be highly susceptible to the hantavirus infection. Also, infected nude rats (rnu/rnu) discharged the infectious viruses, to cause a prevalence of infection among normal cagemates (rnu/+), The i.fection system demonstrated here using Rowett rats (rnu/rnu) may provide a useful model to study the mechanism of the hantavirus infection.

引用

页码：1589 / 1592

页数：4

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