STRUCTURE, CONFORMATION AND IMMUNOLOGY OF SIALIC ACID-CONTAINING POLYSACCHARIDES OF HUMAN PATHOGENIC BACTERIA

被引：72

作者：

JENNINGS, HJ ^{[1
]}

KATZENELLENBOGEN, E ^{[1
]}

LUGOWSKI, C ^{[1
]}

MICHON, F ^{[1
]}

ROY, R ^{[1
]}

KASPER, DL ^{[1
]}

机构：

[1] HARVARD UNIV, SCH MED, CHANNING LAB, BOSTON, MA 02115 USA

来源：

PURE AND APPLIED CHEMISTRY | 1984年 / 56卷 / 07期

关键词：

NEISSERIA MENINGITIDIS - PATHOGENIC BACTERIA - POLYSACCHARIDES - SIALIC ACID - STREPTOCOCCUS;

D O I：

10.1351/pac198456070893

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Capsular polysaccharides of types Ia, Ib, II and III Group B Streptococcus and groups B and C Neisseria meningitidis contain terminal sialic acid in different molecular environments. Experimentation has identified sialic acid as an important factor in the virulence of these organisms and in the human antibody response to their capsular polysaccharide antigens. Although terminal sialic acid is not normally immunogenic, it controls the determinants which are responsible for the production of protective antibodies. Using immunological and NMR spectroscopic techniques on the native and specifically modified polysaccharides, a number of these sialic acid-controled determinants have been identified and located.

引用

页码：893 / 905

页数：13

共 41 条

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