CHANGES IN UNBOUND AND TOTAL VALPROIC ACID CONCENTRATIONS AFTER REPLACEMENT OF CARBAMAZEPINE WITH OXCARBAZEPINE

被引:23
作者
BATTINO, D
CROCI, D
GRANATA, T
BERNARDI, G
MONZA, G
机构
[1] CIBA GEIGY SPA,DEPT MED,POB 88,I-21047 SARONNO,ITALY
[2] C BESTA NEUROL INST,MILAN,ITALY
关键词
VALPROIC ACID; CARBAMAZEPINE; OXCARBAZEPINE; PHARMACOKINETICS;
D O I
10.1097/00007691-199210000-00006
中图分类号
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号
1001 ;
摘要
Total and free valproic acid (VPA) concentrations were measured in patients switched from a combined VPA and carbamazepine (CBZ) to a combined VPA and oxcarbazepine (OXC) therapy, both administered in individualized daily doses. Four young epileptic patients (13-17 years old) were studied for a 12-week period, total and free VPA concentrations being analyzed just before and 4 h after the morning dose, at the end of VPA and CBZ therapy, and 2 and 10 weeks after CBZ was replaced by OXC. The expected increase in the level/dose (L/D) ratio of total VPA observed at the end of the study was preceded by a clear-cut increase in the L/D ratio of free VPA, which led to VPA-related side effects and required the retitration of VPA daily doses.
引用
收藏
页码:376 / 379
页数:4
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