SYNTHESIS OF PEPTIDE DERIVATIVES OF 5-FLUOROURACIL

被引：26

作者：

NICHIFOR, M ^{[1
]}

SCHACHT, EH ^{[1
]}

机构：

[1] STATE UNIV GHENT,DEPT ORGAN CHEM,BIOMAT RES GRP,KRIJGSLAAN 281 S-4,B-9000 GHENT,BELGIUM

来源：

TETRAHEDRON | 1994年 / 50卷 / 12期

关键词：

D O I：

10.1016/S0040-4020(01)90395-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The preparation of di-, tetra- and pentapeptides carrying 5-fluorouracil as an a-substituent of a terminal glycine moiety is described. The dipeptide compounds were synthetized by addition of ethyl glyoxylate to N-(benzyl-oxycarbonyl)-amino acid amides, subsequent acetylation of resulting hydroxyl groups,displacement of acetate groups by 5-fluorouracil, and removal of protective group. Tetra- and pentapeptides were prepared from these dipeptides by coupling methods commonly used in peptide chemistry.

引用

页码：3747 / 3760

页数：14

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