THERMAL REARRANGEMENT OF A PHTHALAZINE TO A QUINAZOLINE

被引：8

作者：

CHAN, KP ^{[1
]}

HAY, AS ^{[1
]}

机构：

[1] MCGILL UNIV,DEPT CHEM,MONTREAL,PQ H3A 2K6,CANADA

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1995年 / 60卷 / 10期

关键词：

D O I：

10.1021/jo00115a031

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

This is the first reported thermal rearrangement reaction of a phthalazine to its structural isomer, a quinazoline. We have found that heating polyphenylated phthalazines 2b-d at 360 degrees C for 30 min gave the corresponding quinazolines in high yield. The less sterically crowded 1,4-bis(4-fluorophenyl)phthalazine (2a) gave only a low yield of quinazoline 3a. X-ray crystallographic analysis on 3b further confirmed our finding.

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页码：3131 / 3134

页数：4

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