PORTAL-VEIN INFUSION OF CANCER CHEMOTHERAPEUTIC AGENT EMULSIFIED WITH LIPIODOL IN REGENERATING LIVER AFTER PARTIAL-HEPATECTOMY IN RATS

被引：4

作者：

MIYAZAKI, M

SUZUKI, H

ITOH, H

KAIHO, T

NAKAJIMA, T

ANDOH, K

ANBIRU, S

OHTAWA, S

OGATA, A

YASUDA, N

HAYASHI, S

NAKAJIMA, N

机构：

[1] First Department of Surgery, School of Medicine, Chiba University, Chiba

来源：

RESEARCH IN EXPERIMENTAL MEDICINE | 1993年 / 193卷 / 04期

关键词：

PORTAL VEIN INFUSION; HEPATIC REGENERATION AFTER HEPATECTOMY; LIPIODOL; AMINOPYRINE N-DEMETHYLASE;

D O I：

10.1007/BF02576231

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Portal vein infusion of aclarubicin (ACR) emulsified with Lipiodol (LP) in regenerating liver after 70% partial hepatectomy in rats was evaluated for its safety and usefulness. DNA synthesis in regenerating liver was transiently suppressed by LP, ACR or LP + ACR, but no obvious inhibition was seen in aminopyrine N-demethylase activity and liver weights. LP significantly enhanced hepatic tissue levels of ACR and its active metabolites by long-term retention in the sinusoidal space. This study demonstrates that in rats LP has a powerful effect on the long-term retention of anticancer agents in the sinusoidal space after infusion into the portal vein, without aggravating hepatic damage by anticancer agents.

引用

页码：231 / 240

页数：10

共 25 条

[1] HEPATIC RESECTION OF COLORECTAL METASTASES - INFLUENCE OF CLINICAL FACTORS AND ADJUVANT INTRAPERITONEAL 5-FLUOROURACIL VIA TENCKHOFF CATHETER ON SURVIVAL [J].