HUMAN RECOMBINANT INTERLEUKIN-1 RECEPTOR ANTAGONIST BLOCKS BONE-RESORPTION INDUCED BY INTERLEUKIN-1-BETA BUT NOT INTERLEUKIN-1-ALPHA

被引：13

作者：

CHOLE, RA

TINLING, SP

FADDIS, BT

机构：

[1] Otolaryngology Research Laboratories, School of Medicine, University of California, Davis, Davis, California

来源：

CALCIFIED TISSUE INTERNATIONAL | 1994年 / 55卷 / 01期

关键词：

IL-1-ALPHA; IL-1-BETA; IL-1 RECEPTOR ANTAGONIST; BONE; CALCIUM; PARATHYROID HORMONE;

D O I：

10.1007/BF00310162

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Both interleukin-1 alpha (IL-1 alpha) and interleukin-1 beta (IL-1 beta) are powerful stimulators of bone resorption in vivo and in vitro. Interleukin-1 receptor antagonist (IL-1ra) binds to many interleukin-1 receptors. It does not activate the receptor and effectively blocks the action of IL-1 alpha and IL-1 beta. In this study, human recombinant IL-1ra, at 100-fold excess, was found to block bone resorption in cultured mouse calvaria due to IL-1 beta but not IL-1 alpha. These observations may be explained by differential affinities of receptors for IL-1 alpha, IL-1 beta and rhIL-1ra on target bone cells.

引用

页码：12 / 15

页数：4

共 37 条

[1]

AKATSU T, 1991, J BONE MINER RES, V6, P183

[2]

ALEXANDER HR, 1992, SURGERY, V112, P188

[3] CYTOKINES AND CYTOKINE INHIBITORS OR ANTAGONISTS IN RHEUMATOID-ARTHRITIS [J].

AREND, WP ;

DAYER, JM .

ARTHRITIS AND RHEUMATISM, 1990, 33 (03) :305-315

[4]

BENJAMIN D, 1990, J BIOL CHEM, V265, P9943

[5] BOLUS INJECTIONS OF RECOMBINANT HUMAN INTERLEUKIN-1 CAUSE TRANSIENT HYPOCALCEMIA IN NORMAL MICE [J].

BOYCE, BF ;

YATES, AJP ;

MUNDY, GR .

ENDOCRINOLOGY, 1989, 125 (05) :2780-2783

[6] EFFECTS OF INTERLEUKIN-1 ON BONE TURNOVER IN NORMAL MICE [J].

BOYCE, BF ;

AUFDEMORTE, TB ;

GARRETT, IR ;

YATES, AJP ;

MUNDY, GR .

ENDOCRINOLOGY, 1989, 125 (03) :1142-1150

[7] PURIFICATION, CLONING, EXPRESSION AND BIOLOGICAL CHARACTERIZATION OF AN INTERLEUKIN-1 RECEPTOR ANTAGONIST PROTEIN [J].

CARTER, DB ;

DEIBEL, MR ;

DUNN, CJ ;

TOMICH, CSC ;

LABORDE, AL ;

SLIGHTOM, JL ;

BERGER, AE ;

BIENKOWSKI, MJ ;

SUN, FF ;

MCEWAN, RN ;

HARRIS, PKW ;

YEM, AW ;

WASZAK, GA ;

CHOSAY, JG ;

SIEU, LC ;

HARDEE, MM ;

ZURCHERNEELY, HA ;

REARDON, IM ;

HEINRIKSON, RL ;

TRUESDELL, SE ;

SHELLY, JA ;

EESSALU, TE ;

TAYLOR, BM ;

TRACEY, DE .

NATURE, 1990, 344 (6267) :633-638

[8] 2 HIGH-AFFINITY INTERLEUKIN-1 RECEPTORS REPRESENT SEPARATE GENE-PRODUCTS [J].

CHIZZONITE, R ;

TRUITT, T ;

KILIAN, PL ;

STERN, AS ;

NUNES, P ;

PARKER, KP ;

KAFFKA, KL ;

CHUA, AO ;

LUGG, DK ;

GUBLER, U .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1989, 86 (20) :8029-8033

[9]

DINARELLO CA, 1991, BLOOD, V77, P1627

[10] DETECTION AND CHARACTERIZATION OF HIGH-AFFINITY PLASMA-MEMBRANE RECEPTORS FOR HUMAN INTERLEUKIN-1 [J].

DOWER, SK ;

KRONHEIM, SR ;

MARCH, CJ ;

CONLON, PJ ;

HOPP, TP ;

GILLIS, S ;

URDAL, DL .

JOURNAL OF EXPERIMENTAL MEDICINE, 1985, 162 (02) :501-515

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