NICOTINE, COTININE, AND TRANS-3-HYDROXYCOTININE LEVELS IN SEMINAL PLASMA OF SMOKERS - EFFECTS ON SPERM PARAMETERS

被引：90

作者：

PACIFICI, R ^{[1
]}

ALTIERI, I ^{[1
]}

GANDINI, L ^{[1
]}

LENZI, A ^{[1
]}

PICHINI, S ^{[1
]}

ROSA, M ^{[1
]}

ZUCCARO, P ^{[1
]}

DONDERO, F ^{[1
]}

机构：

[1] UNIV ROMA LA SAPIENZA,V MED CLIN,DEPT SEMINOL & IMMUNOL REPROD,I-00185 ROME,ITALY

来源：

THERAPEUTIC DRUG MONITORING | 1993年 / 15卷 / 05期

关键词：

SMOKE; NICOTINE METABOLITES; SPERM PARAMETERS;

D O I：

10.1097/00007691-199310000-00002

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Sperm samples from 44 cigarette smokers and 50 nonsmokers attending an infertility clinic were examined by high-performance liquid chromatography (HPLC) assay and HPLC-mass spectrometry for the presence of nicotine (NIC), cotinine (COT), and trans-3'-hydroxycotinine (THOC) in seminal plasma. Smokers were found to have levels of COT and THOC in seminal plasma that were similar to those found in serum. The level of NIC was significantly increased in seminal plasma compared to serum. Total motility of spermatozoa was significantly and negatively correlated to COT and THOC levels in seminal plasma. Forward motility of spermatozoa was correlated only with cotinine semen levels. On the basis of these results, we suggest that the presence of tobacco smoke constituents in seminal plasma could provide a warning of the adverse effects of cigarette smoke on the physiology of reproduction.

引用

页码：358 / 363

页数：6

共 25 条

[1]

BENOWITZ NL, 1988, NEW ENGL J MED, V319, P1318

[2] STATISTICAL-ANALYSIS IN ANDROLOGY [J].

CULASSO, F ;

LENZI, A ;

FAVILLI, S ;

DONDERO, F .

ARCHIVES OF ANDROLOGY, 1991, 26 (03) :163-172

[3]

DAWSON GW, 1982, PHARMACOL THERAPEUT, V15, P207

[4] THE CAUSES OF CANCER - QUANTITATIVE ESTIMATES OF AVOIDABLE RISKS OF CANCER IN THE UNITED-STATES TODAY [J].

DOLL, R ;

PETO, R .

JNCI-JOURNAL OF THE NATIONAL CANCER INSTITUTE, 1981, 66 (06) :1191-+

[5]

EVANS HJ, 1981, LANCET, V1, P627

[6]

Fraser L.R., 1984, Oxford Reviews of Reproductive Biology, V6, P174

[7] SMOKING AND REPRODUCTION - SHORT AND LONG-TERM EFFECTS AND BENEFITS OF SMOKING CESSATION [J].

FREDRICSSON, B ;

GILLJAM, H .

ACTA OBSTETRICIA ET GYNECOLOGICA SCANDINAVICA, 1992, 71 (08) :580-592

[8] TESTICULAR FUNCTION IN POTENTIAL SPERM DONORS - NORMAL RANGES AND THE EFFECTS OF SMOKING AND VARICOCELE [J].

HANDELSMAN, DJ ;

CONWAY, AJ ;

BOYLAN, LM ;

TURTLE, JR .

INTERNATIONAL JOURNAL OF ANDROLOGY, 1984, 7 (05) :369-382

[9]

JARVIS M, 1984, J EPIDEMIOL COMMUN H, V38, P335, DOI 10.1136/jech.38.4.335

[10]

KOOP E, 1988, CDC888406 US DEP HLT

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