LOSS OF NEURONS AFTER LONG-TERM ADRENALECTOMY IN THE ADULT-RAT HIPPOCAMPAL-FORMATION

被引：22

作者：

ADEM, A ^{[1
]}

ISLAM, A ^{[1
]}

BOGDANOVIC, N ^{[1
]}

CARLSTROM, K ^{[1
]}

WINBLAD, B ^{[1
]}

机构：

[1] HUDDINGE HOSP,KAROLINSKA INST,DEPT OBSTET & GYNAECOL,S-14186 HUDDINGE,SWEDEN

来源：

NEUROREPORT | 1994年 / 5卷 / 17期

关键词：

ADRENALECTOMY; HIPPOCAMPUS; NEURONAL DEGENERATION; DENTATE GYRUS; PYRAMIDAL CELLS;

D O I：

10.1097/00001756-199411000-00020

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

THE effects of long-term adrenalectomy (ADX) on hippocampal neurones were investigated 5 months after surgery in male Sprague-Dawley rats. Cells in Nissl-stained sections from ADX rats were counted and compared with those in sections from sham-operated rats. The ADX rats had a significantly reduced number of dentate granule cells. A novel finding was a significant reduction in the number of pyramidal cells in CA1, CA2, CA3 and CA4 regions of the hippocampus. Thus long-term adrenalectomy causes loss of dentate granule cells and pyramidal neurones of the hippocampus.

引用

页码：2285 / 2288

页数：4

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