FUNCTIONAL-GROUP HYBRIDS - REACTIVITY OF ALPHA'-NUCLEOFUGE ALPHA,BETA-UNSATURATED KETONES .1. REACTIONS WITH ORGANOCOPPER REAGENTS

被引：17

作者：

BARBEE, TR ^{[1
]}

ALBIZATI, KF ^{[1
]}

机构：

[1] WAYNE STATE UNIV,DEPT CHEM,DETROIT,MI 48202

来源：

JOURNAL OF ORGANIC CHEMISTRY | 1991年 / 56卷 / 24期

关键词：

D O I：

10.1021/jo00024a014

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of alpha-nucleofuge alpha',beta'-unsaturated ketones encompassing a variety of structural types and nucleofuges was prepared. Treatment of these compounds with lithium dimethylcuprate or methylcopper leads primarily to either reductive cleavage of the alpha-nucleofuge or conjugate addition. Good alpha-nucleofuges favored the reduction pathway while poorer nucleofuges favored conjugate addition.

引用

页码：6764 / 6773

页数：10

共 36 条

[1] CONVERGENCE, MOLECULAR COMPLEXITY, AND SYNTHETIC ANALYSIS [J].