CRYSTAL AND MOLECULAR-STRUCTURE OF A DNA FRAGMENT CONTAINING A 2-AMINOADENINE MODIFICATION - THE RELATIONSHIP BETWEEN CONFORMATION, PACKING AND HYDRATION IN Z-DNA HEXAMERS

被引：33

作者：

SCHNEIDER, B ^{[1
]}

GINELL, SL ^{[1
]}

JONES, R ^{[1
]}

GAFFNEY, B ^{[1
]}

BERMAN, HM ^{[1
]}

机构：

[1] RUTGERS STATE UNIV,DEPT CHEM,NEW BRUNSWICK,NJ 08903

来源：

BIOCHEMISTRY | 1992年 / 31卷 / 40期

关键词：

D O I：

10.1021/bi00155a014

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The crystal and molecular structure of d(CGUA'CG)2 (where A' is 2-aminoadenine) has been determined and refined to an R factor of 13.8% for data 8.0-1.3 angstrom. The structure is very similar to the original Z-DNA structures with the sequence d(CGCGCG)2 [Gessner, R. V., Frederick, C. A., Quigley, G. J., Rich, A., & Wang, A. H.-J. (1989) J. Biol. Chem. 264, 7921 ] and shows that the substitution of 2-aminoadenine-uracil base pairs in the two central steps is consistent with Z-DNA formation. In addition, we show how waters mediating intermolecular interactions may help to explain the ZI-ZII conformational pattern found in many Z-DNA structures.

引用

页码：9622 / 9628

页数：7

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