PREPARATION OF THE ENANTIOMERS OF THE ANALGESIC E-3710

被引：15

作者：

HUESORODRIGUEZ, JA

BERROCAL, J

GUTIERREZ, B

FARRE, AJ

FRIGOLA, J

机构：

[1] LABS DR ESTEVE SA,DEPT MED CHEM,AV MARE DEU MONTSERRAT 221,E-08026 BARCELONA,SPAIN

[2] LABS DR ESTEVE SA,DEPT PHARMACOL,E-08026 BARCELONA,SPAIN

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1993年 / 3卷 / 02期

关键词：

D O I：

10.1016/S0960-894X(01)80890-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Both enantiomers of E-3710, a novel analgesic, were prepared by a practical resolution method and their absolute stereochemistries assigned by asymmetric synthesis from ethyl (R)-mandelate. Their pharmacological properties were compared-with those of the racemic compound, and no significant difference was observed.

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页码：269 / 272

页数：4

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