An Overview of Valuable Scientific Models for Diabetes Mellitus

被引:46
作者
Akash, Muhammad Sajid Hamid [1 ,2 ]
Rehman, Kanwal [1 ]
Chen, Shuqing [1 ]
机构
[1] Zhejiang Univ, Inst Pharmacol Toxicol & Biochem Pharmaceut, Coll Pharmaceut Sci, Hangzhou, Zhejiang, Peoples R China
[2] Govt Coll Univ Faisalabad, Coll Pharm, Faisalabad, Pakistan
关键词
Biomarkers; biosensors; Diabetic animal models; High throughput screening; oxidative stress; nonmaterials in diabetes; metabolic fingerprinting; glucolipotoxicity;
D O I
10.2174/15733998113099990062
中图分类号
R5 [内科学];
学科分类号
1002 [临床医学]; 100201 [内科学];
摘要
Diabetes mellitus is one of the major clinical problems worldwide. Previously, most of the investigational studies for identification of disease and new therapies were based on animal studies; however, present research methods involve high throughput screening, molecular targeting, nanotechnology for recent discovery of drugs and disease identification to combat against hazardous diseases like diabetes mellitus. In this review, we have depicted outlines enfolding various disease-specific animal modeling, sensing technologies, biomarker analysis, and novel scientific techniques that could be helpful in exploring the impending strategies for diabetes detection and treatment. To conclude, we believe that endorsement and upgrading of such novel high throughput screening assays and nanotechnology described herein may surely represent a significant improvement in the capability for screening and identifying the population at elevated risk of expected diabetes. Thereby in future, appreciation of such investigational techniques and technologies including metabolomics and genetic screening may help in early prediction of diabetes in patients at risk and may display a significant improvement over the researchers conducted after the declaration of the disease.
引用
收藏
页码:286 / 293
页数:8
相关论文
共 105 条
[1]
Prevention and Treatment of Diabetic Retinopathy: Evidence from Clinical Trials and Perspectives [J].
Abbate, Manuela ;
Cravedi, Paolo ;
Iliev, Ilian ;
Remuzzi, Giuseppe ;
Ruggenenti, Piero .
CURRENT DIABETES REVIEWS, 2011, 7 (03) :190-200
[2]
Alternate therapy of Type 2 diabetes mellitus (T2DM) with Nigella (Ranunculaceae) [J].
Akash, M. S. H. ;
Rehman, K. ;
Rasool, F. ;
Sethi, A. ;
Abrar, M. A. ;
Irshad, A. ;
Abid, A. ;
Murtaza, G. .
JOURNAL OF MEDICINAL PLANTS RESEARCH, 2011, 5 (31) :6885-6889
[3]
Akash MSH, 2013, J PROTEOM BIOINFORM, V6, P38
[4]
Assessment of release kinetics, stability and polymer interaction of poloxamer 407-based thermosensitive gel of interleukin-1 receptor antagonist [J].
Akash, Muhammad Sajid Hamid ;
Rehman, Kanwal ;
Sun, Hongying ;
Chen, Shuqing .
PHARMACEUTICAL DEVELOPMENT AND TECHNOLOGY, 2014, 19 (03) :278-284
[5]
Interleukin-1 receptor antagonist improves normoglycemia and insulin sensitivity in diabetic Goto-Kakizaki-rats [J].
Akash, Muhammad Sajid Hamid ;
Rehman, Kanwal ;
Sun, Hongyin ;
Chen, Shuqing .
EUROPEAN JOURNAL OF PHARMACOLOGY, 2013, 701 (1-3) :87-95
[6]
Sustained Delivery of IL-1Ra from PF127-Gel Reduces Hyperglycemia in Diabetic GK-Rats [J].
Akash, Muhammad Sajid Hamid ;
Rehman, Kanwal ;
Sun, Hongying ;
Chen, Shuqing .
PLOS ONE, 2013, 8 (02)
[7]
Role of inflammatory mechanisms in pathogenesis of type 2 diabetes mellitus [J].
Akash, Muhammad Sajid Hamid ;
Rehman, Kanwal ;
Chen, Shuqing .
JOURNAL OF CELLULAR BIOCHEMISTRY, 2013, 114 (03) :525-531
[8]
Sustained Delivery of IL-1Ra from Pluronic F127-Based Thermosensitive Gel Prolongs its Therapeutic Potentials [J].
Akash, Muhammad Sajid Hamid ;
Rehman, Kanwal ;
Li, Ni ;
Gao, Jian-Qing ;
Sun, Hongying ;
Chen, Shuqing .
PHARMACEUTICAL RESEARCH, 2012, 29 (12) :3475-3485
[9]
Interleukin-1 Receptor Antagonist: A New Therapy for Type 2 Diabetes Mellitus [J].
Akash, Muhammad Sajid Hamid ;
Shen, Qi ;
Rehman, Kanwal ;
Chen, Shuqing .
JOURNAL OF PHARMACEUTICAL SCIENCES, 2012, 101 (05) :1647-1658
[10]
Hypoxia and Oxidative Stress in the Causation of Diabetic Retinopathy [J].
Arden, Geoffrey B. ;
Sivaprasad, Sobha .
CURRENT DIABETES REVIEWS, 2011, 7 (05) :291-304