FACILE SYNTHESIS OF A BETA-(1-3)-LINKED GAL-GALACTAL DISACCHARIDE AND ITS USE IN N-IODOSUCCINIMIDE-ACTIVATED O-GLYCOPEPTIDE SYNTHESIS

被引：25

作者：

KESSLER, H ^{[1
]}

KLING, A ^{[1
]}

KOTTENHAHN, M ^{[1
]}

机构：

[1] DEGUSSA AG,ZN WOLFGANG FCO,W-6450 HANAU 1,GERMANY

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION IN ENGLISH | 1990年 / 29卷 / 04期

关键词：

D O I：

10.1002/anie.199004251

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The fact that compound 1 can now be synthesized in four steps with an overall yield of 21 % should ensure its broader utilization in the NIS‐activated synthesis of glycopeptides. The key intermediate in the process is the selectively protected galactaldehyde derivative 2.1 reacts not only with the universally applicable Fmoc‐Ser‐OBzl subunit but also with a cyclic glycophorin‐A fragment. (Figure Presented.) Copyright © 1990 by VCH Verlagsgesellschaft mbH, Germany

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页码：425 / 427

页数：3

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