AGGREGATION PROPERTIES OF GM3 GANGLIOSIDE (II3NEU5ACLACCER) IN AQUEOUS-SOLUTIONS

被引：54

作者：

SONNINO, S ^{[1
]}

CANTU, L ^{[1
]}

ACQUOTTI, D ^{[1
]}

CORTI, M ^{[1
]}

TETTAMANTI, G ^{[1
]}

机构：

[1] UNIV PAVIA,DEPT ELECTR,I-27100 PAVIA,ITALY

来源：

CHEMISTRY AND PHYSICS OF LIPIDS | 1990年 / 52卷 / 3-4期

关键词：

ganglioside aggregates; ganglioside derivatives; gangliosides; light scattering; vesicles;

D O I：

10.1016/0009-3084(90)90119-C

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The aggregative properties of highly pure GM3 ganglioside in aqueous solution have been studied by static and dynamic laser light scattering measurements and fluorescence spectroscopy experiments performed by the use of a GM3 derivative containing the pyrene group at the end of the fatty acid moiety. GM3 ganglioside spontaneously aggregates as unilamellar vesicles, down to a concentration of 1.25 × 10-8 M, showing molecular weight and hydrodynamic radius ranging from 15,000 to 30,000 kDa and from 350 to 470 Å, respectively. GM3 vesicles are stable with dilution and can be stored at room temperature for some weeks without appreciable change. © 1990.

引用

页码：231 / 241

页数：11

共 45 条

[1] A NEW CHEMICAL PROCEDURE FOR THE PREPARATION OF GANGLIOSIDES CARRYING FLUORESCENT OR PARAMAGNETIC PROBES ON THE LIPID MOIETY [J].