EFFECT OF 5-HT RECEPTOR AND ADRENOCEPTOR ANTAGONISTS ON MICTURITION IN CONSCIOUS CATS

被引：51

作者：

ESPEY, MJ ^{[1
]}

DOWNIE, JW ^{[1
]}

FINE, A ^{[1
]}

机构：

[1] DALHOUSIE UNIV,FAC MED,DEPT PHARMACOL & PHYSIOL,HALIFAX B3H 4H2,NS,CANADA

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 1992年 / 221卷 / 01期

关键词：

MICTURITION; METHYSERGIDE; PHENTOLAMINE; PRAZOSIN; (CAT);

D O I：

10.1016/0014-2999(92)90788-6

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Micturition was induced in awake cats by infusing saline into the bladder at a physiological filling rate. Methysergide, a serotonergic antagonist given intrathecally, decreased the volume at which micturition occurred. Phentolamine, a non-specific alpha-adrenoceptor antagonist, also decreased volume threshold. Prazosin, an alpha1-adrenoceptor antagonist, was without effect on micturition. These results imply that 5-HT receptors and alpha2-adrenoceptors may be inhibitory to micturition at a spinal level.

引用

页码：167 / 170

页数：4

共 11 条

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