NOVEL ASYMMETRIC-SYNTHESIS OF GAMMA-ALKYLATED LACTONES VIA SUCCESSIVE ALKYLATION AND REDUCTION OF CHIRAL CYCLIC IMIDES WITH C-2-SYMMETRY

被引：28

作者：

YODA, H

SHIRAKAWA, K

TAKABE, K

机构：

来源：

CHEMISTRY LETTERS | 1991年 / 03期

关键词：

D O I：

10.1246/cl.1991.489

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Consecutive treatment of chiral cyclic imides containing a C2-axis of symmetry with Grignard reagents and sodium borohydride followed by cyclization furnished gamma-alkylated lactones with high diastereoselectivity. Products were converted to synthetically useful R-butenolides after removal of the chirality inducing groups.

引用

页码：489 / 490

页数：2

共 15 条

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