OPTIMIZATION OF DIRECT COMPRESSION TABLET FORMULATIONS FOR USE IN TROPICAL COUNTRIES

被引：4

作者：

BOS, CE ^{[1
]}

BOLHUIS, GK ^{[1
]}

LERK, CF ^{[1
]}

DEBOER, JH ^{[1
]}

DUINEVELD, CAA ^{[1
]}

SMILDE, AK ^{[1
]}

DOORNBOS, DA ^{[1
]}

机构：

[1] UNIV GRONINGEN,DEPT ANALYT CHEM & TOXICOL,CHEMOMETR RES GRP,9713 AW GRONINGEN,NETHERLANDS

来源：

DRUG DEVELOPMENT AND INDUSTRIAL PHARMACY | 1991年 / 17卷 / 18期

关键词：

D O I：

10.3109/03639049109048088

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

With the aid of a combined mixture- and factorial- design, 2 standard tablet formulations were selected suitable for use in tropical countries. The formulations were based on native ingredients or ingredients that are available worldwide. The selection of the standard formulations was based on both the initial tablet properties of the formulations one day after preparation as well as the physical stability after storage under tropical conditions. The selected formulations were evaluated by adding model drugs (diazepam, 2 mg per tablet or hydrochlorthiazide, 100 mg per tablet) and measuring tablet properties, not only one day after preparation, but also after storage under tropical conditions. Both selected tablet formulations were suitable standard formulations for tablets prepared by direct compression for use in tropical countries.

引用

页码：2477 / 2496

页数：20

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