SELECTIVE ADHERENCE OF A SUCRALFATETETRACYCLINE COMPLEX TO GASTRIC-ULCERS - IMPLICATIONS FOR THE TREATMENT OF HELICOBACTER-PYLORI

被引：18

作者：

YOKEL, RA

DICKEY, KM

GOLDBERG, AH

机构：

[1] UNIV KENTUCKY,GRAD CTR TOXICOL,LEXINGTON,KY

[2] UNIV KENTUCKY,DIV LAB ANIM RESOURCES,LEXINGTON,KY

[3] DARBY PHARMACEUT,ROCKVILLE CTR,NEW YORK,NY

来源：

BIOPHARMACEUTICS & DRUG DISPOSITION | 1995年 / 16卷 / 06期

关键词：

HELICOBACTER PYLORI; PEPTIC ULCER MODEL; RABBIT; SUCRALFATE TETRACYCLINE COMPLEX; TETRACYCLINE;

D O I：

10.1002/bdd.2510160605

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The adherence of a sucralfate-tetracycline complex to gastric ulcers and to nearby nonulcer sites was determined in the rabbit antrum. Persistent gastric ulcers were produced by a previously described method. The presence of the complex was assessed 1 and 4 h after dosing. Drug adherence was determined by quantitation of aluminum in stomach wall biopsies. Significantly more aluminum adhered to ulcer sites than to nearby nonulcer sites. Adherence of the complex did not significantly decrease from 1 to 4 h. The complexation of tetracycline to sucralfate did not alter the selective adherence of sucralfate to gastric ulcers, providing a mechanism of ulcer site-selective drug delivery in the treatment of Helicobacter pylori gastric ulcer disease.

引用

页码：475 / 479

页数：5

共 17 条

[1]

ATESHKADI A, 1993, CLIN PHARMACY, V12, P34

[2]

BELL GD, 1992, ALIMENT PHARM THERAP, V6, P427

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