5-DIETHOXYPHOSPHORYL-5-METHYL-1-PYRROLINE N-OXIDE (DEPMPO) - A NEW PHOSPHORYLATED NITRONE FOR THE EFFICIENT IN-VITRO AND IN-VIVO SPIN-TRAPPING OF OXYGEN-CENTERED RADICALS

被引：117

作者：

FREJAVILLE, C ^{[1
]}

KAROUI, H ^{[1
]}

TUCCIO, B ^{[1
]}

LEMOIGNE, F ^{[1
]}

CULCASI, M ^{[1
]}

PIETRI, S ^{[1
]}

LAURICELLA, R ^{[1
]}

TORDO, P ^{[1
]}

机构：

[1] UNIV AIX MARSEILLE 1,CTR ST JEROME,STRUCT & REACT ESPECES PARAMAGNET LAB,CNRS,URA 1412,F-13397 MARSEILLE 20,FRANCE

来源：

JOURNAL OF THE CHEMICAL SOCIETY-CHEMICAL COMMUNICATIONS | 1994年 / 15期

关键词：

D O I：

10.1039/c39940001793

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

5-Diethoxyphosphoryl-5-methyl-1-pyrroline N-oxide (DEPMPO), a newly synthesized spin trap, is used for the in vitro spin trapping of hydroxyl and superoxide radicals, and though the spin trapping rates are close to those reported for 5,5-dimethyl-1 -pyrroline N-oxide (DMPO),the DEPMPO-superoxide spin adduct is significantly more persistent than its DMPO analogue, a difference which allows the detection of superoxide during the reperfusion of ischaemic isolated rat hearts.

引用

页码：1793 / 1794

页数：2

共 18 条

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