EXON-2 OF THE GENE FOR NEURAL CELL-ADHESION MOLECULE L1 IS ALTERNATIVELY SPLICED IN B-CELLS

被引：34

作者：

JOUET, M ^{[1
]}

ROSENTHAL, A ^{[1
]}

KENWRICK, S ^{[1
]}

机构：

[1] INST MOLEC BIOTECHNOL,JENA,GERMANY

来源：

MOLECULAR BRAIN RESEARCH | 1995年 / 30卷 / 02期

关键词：

L1CAM; HYDROCEPHALUS; SPLICING; ALTERNATIVE MESSENGER-RNA; EXON; 2;

D O I：

10.1016/0169-328X(95)00027-P

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

L1CAM is a neural cell adhesion molecule expressed mainly on neurones' cell surface and plays an important role in the developing fetal brain. Recently, we have shown that mutations in the gene encoding L1CAM are responsible for three related neurological disorders including the most common form of inherited hydrocephalus. During our genetic analysis, we have discovered that L1CAM is also expressed on the surface of B cells but that the messenger RNA in this tissue is different to that in brain through alternative splicing of the L1 gene. This indicates that this region of the L1 molecule has a distinct role in brain cells compared to B lymphocytes and confirms its importance in brain development.

引用

页码：378 / 380

页数：3

共 13 条

[1]

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