[DY-166]DYSPROSIUM/[HO-166]HOLMIUM IN-VIVO GENERATOR

被引：22

作者：

SMITH, SV

DIBARTOLO, N

MIRZADEH, S

LAMBRECHT, RM

KNAPP, FFR

HETHERINGTON, EL

机构：

[1] AUSTRALIAN NUCL SCI & TECHNOL ORG,BIOMED & HLTH PROGRAM,MENAI,NSW 2234,AUSTRALIA

[2] OAK RIDGE NATL LAB,DIV HLTH SCI RES,NUCL MED GRP,OAK RIDGE,TN 37831

[3] UNIV WOLLONGONG,DEPT CHEM,WOLLONGONG,NSW 2522,AUSTRALIA

来源：

APPLIED RADIATION AND ISOTOPES | 1995年 / 46卷 / 08期

关键词：

D O I：

10.1016/0969-8043(94)00149-T

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel approach for the delivery of Ho-166 (t1/2 = 26.6 h) to tissue is via the in vivo decay of its 81.5 h parent, Dy-166-an in vivo generator system. A critical question for the in vivo Dy-166/Ho-166 generator system is whether translocation of the daughter nucleus occurs. The in vitro and in vivo integrity of the [Dy-166]Dy/Ho-166-DTPA complex was investigated and results indicated that no translocation of the daughter nucleus occurs subsequent to beta(-) decay of Dy-166. Biodistribution studies of [Dy-166]Dy-DTPA showed that the ratio of Dy-166/Ho-166 in bone remains constant (+/-7%) over a 20 h period, indicating no significant in vivo loss of Ho-166 from the complex. Increasing the in vivo residence time of [Dy-166]Dy-DTPA complex attached to HSA gave similar results.

引用

页码：759 / 764

页数：6

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