PREPARATION OF ACRYLAMIDE MALEIC-ACID HYDROGELS AND THEIR BIOCOMPATIBILITY WITH SOME BIOCHEMICAL PARAMETERS OF HUMAN SERUM

被引：36

作者：

SARAYDIN, D

KARADAG, E

CETINKAYA, S

GUVEN, O

机构：

[1] CUMHURIYET UNIV,FAC MED,SIVAS 58140,TURKEY

[2] UNIV HACETTEPE,DEPT CHEM,ANKARA 06532,TURKEY

来源：

RADIATION PHYSICS AND CHEMISTRY | 1995年 / 46卷 / 4-6期

关键词：

ACRYLAMIDE MALEIC ACID HYDROGEL; SWELLING; HUMAN SERUM; BIOCOMPATIBILITY;

D O I：

10.1016/0969-806X(95)00318-R

中图分类号：

O64 [物理化学（理论化学）、化学物理学];

学科分类号：

070304 ; 081704 ;

摘要：

In this study, the biocompatibility of acrylamide and acrylamide/maleic acid hydrogels prepared by using gamma-rays has been investigated against some biochemical parameters of human serum. First, the swelling kinetics of acrylamide and acrylamide/maleic acid hydrogels were investigated in distilled water and physiological saline solution and some swelling and diffusion parameters have been were incubated in 10 different human sera for 24 hours and their biocompatibility with some biochemical parameters have been investigated. No significant difference in values before and after the test procedures have been found. It is therefore concluded that acrylamide and acrylamide/maleic acid hydrogels are biocompatible.

引用

页码：1049 / 1052

页数：4

共 13 条

[1]

ALLEN GG, 1980, CONTROLLED RELEASE T, V2, P7

[2]

BUCKLEY JD, 1992, J POLYM SCI, V56, P175

[3]

CARDARELLI NF, 1980, CONTROLLED RELEASE T, V1, P55

[4]

CHAPIRO A, 1962, RAD CHEM POLYM SYSTE, P236

[5] PREPARATION AND CHARACTERIZATION OF POLY(N-VINYL 2-PYRROLIDONE) HYDROGELS [J].

GUVEN, O ;

SEN, M .

POLYMER, 1991, 32 (13) :2491-2495

[6]

KARADAG E, 1994, CHEM ABSTR, V120, P10

[7]

MURRAY RK, 1993, HARPERS BIOCH, P859

[8]

Peppas N.A., 1986, HYDROGELS MED PHARM

[9] SYNTHETIC HYDROGELS AS DRUG DELIVERY SYSTEMS [J].

ROORDA, WE ;

BODDE, HE ;

DEBOER, AG ;

JUNGINGER, HE .

PHARMACEUTISCH WEEKBLAD-SCIENTIFIC EDITION, 1986, 8 (03) :165-189

[10] RADIATION CROSSLINKED HYDROGELS FROM ACRYLAMIDE WATER SOLUTIONS [J].

ROSIAK, J ;

BURCZAK, K ;

CZOLCZYNSKA, T ;

PEKALA, W .

RADIATION PHYSICS AND CHEMISTRY, 1983, 22 (3-5) :917-928

← 1 2 →