QUANTITATIVE-ANALYSIS OF CHLORPROMAZINE BY ELECTRON-SPIN-RESONANCE (ESR) SPECTROSCOPY

被引：12

作者：

MINAKATA, K ^{[1
]}

SUZUKI, O ^{[1
]}

ISHIKAWA, Y ^{[1
]}

SENO, H ^{[1
]}

ASANO, M ^{[1
]}

机构：

[1] HAMAMATSU UNIV SCH MED, DEPT PHARM, HAMAMATSU, SHIZUOKA 431-31, JAPAN

来源：

FORENSIC SCIENCE INTERNATIONAL | 1991年 / 50卷 / 02期

关键词：

CHLORPROMAZINE; ESR; SPECTROPHOTOMETRY; 2,3-DICHLORO-5,6-DICYANO-PARA-BENZOQUINONE;

D O I：

10.1016/0379-0738(91)90148-C

中图分类号：

DF [法律]; D9 [法律]; R [医药、卫生];

学科分类号：

0301 ; 10 ;

摘要：

A simple and sensitive method is described for quantitative analysis of chlorpromazine in blood, serum, urine and tissue homogenate. The chlorpromazine cation radical produced by adding perchloric acid and 2,3-dichloro-5,6-dicyano-p-benzoquinone to the sample can be detected by the ESR method at room temperature. The sensitivity limit is 10 ng, that is, 20-mu-l of the solution containing 0.5-mu-g chlorpromazine/ml. The time needed for the measurement is within 10 min. The chlorpromazine radical thus produced is very stable; for example, 95% of the radical was observed after 24 h. The advantage of this method is discussed by comparing with the ordinary spectrophotometry which requires the purification of the sample.

引用

页码：167 / 177

页数：11

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